Our Research Team in Structural Biology, Protein Engineering & Biomolecular Characterization
Welcome to the Doucet Lab at the Institut national de la recherche scientifique (INRS) – Université du Québec (Montréal, Canada).
We investigate protein structure, dynamics, and function and develop innovative biochemical, biophysical, and AI-driven tools to engineer enzymes and characterize complex biological systems.
Our core expertise spans:
- NMR spectroscopy and X-ray crystallography for high-resolution structural and dynamic analysis
- Protein & enzyme engineering, nanobody redesign
- Artificial intelligence–guided protein design, including our in-house server platform SPASE (Soluble Protein Analog Selection Engine)
- Biomolecular fingerprinting of food matrices using NMR and chemometrics
Learn more about our research
View our publications
Equity, Diversity & Inclusion
Our group values and actively promotes diversity. We welcome trainees from all backgrounds and are committed to maintaining an inclusive and collaborative environment where every team member can thrive.
We strongly support the participation of women, LGBTQ+ individuals, and other underrepresented groups in science and encourage all motivated trainees to join our research programs.
What we do
Structural biology & enzyme engineering
We investigate protein structure, dynamics and catalysis using NMR, X-ray crystallography and mutagenesis to understand how motions shape enzymatic function and to redesign proteins with new activities.
SPASE – AI-guided protein design
SPASE (Soluble Protein Analog Selection Engine) is our in-house AI-assisted design pipeline that combines sequence design, stability and solubility predictions and rapid structure prediction to generate experimentally tractable protein variants.
Biomolecular & food systems characterization
We develop NMR models to study maple syrup chemistry, terroir signatures, quality defects and other complex food and biomolecular systems.
Training environment
The Doucet Lab is part of a graduate-only research institute dedicated to high-impact science. Trainees benefit from access to advanced structural biology, analytical chemistry and biophysics platforms, as well as interdisciplinary collaborations and industrial partnerships.