Mighel is an M.Sc. student co-supervised by Nicolas Doucet and Prof. Marc-André Gauthier (INRS), working at the interface of structural biology, chemical biology and biomolecular engineering.
His research focuses on the design and characterization of multivalent nanobody complexes targeting human RNases and galectins, with the goal of modulating molecular recognition, stability and functional interactions.
His project combines:
- Nanobody engineering and multivalent scaffold design
- X-ray crystallography for structural analysis
- Protein biophysics (binding affinity, stability, ligand interactions)
- Structure–function analysis of RNase and galectin complexes
Through this interdisciplinary work, Mighel aims to understand how multivalency influences biomolecular recognition and to develop next-generation nanobody architectures for biochemical and biotechnological applications.